Patients or loved ones of those who developed gynecomastia or permanent injury or who died after taking Risperdal may be eligible for compensation and should seek legal advice. Needles for intramuscular injection a 21 G UTW 1-inch needle with needle protection device for deltoid administration and a 20 G TW 2-inch needle with needle protection device for gluteal administration. Secretion of prolactin is responsible for female lactation or milk production after giving birth. generic estreva purchase online pharmacy estreva
NMS have been reported. FDA pregnancy category C. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Table 9 shows the EPS data from the pooled schizoaffective disorder trials.
Silverman, E. 11 September 2012. After oral administration, overall mean elimination half-life for active moiety risperidone plus 9-hydroxyrisperidone is about 20 hours. The findings were presented at the annual meeting of the American Psychiatric Association. Some medical conditions may interact with liothyronine. She experienced jaundice, fever, and bruising, but eventually recovered after receiving plasmapheresis.
All patients met DSM-IV diagnostic criteria for schizophrenia and were experiencing an acute episode at time of enrollment. Administer orally once or twice in equally divided doses daily without regard to meals. CYP 2D6 metabolizers convert it much more slowly. Day 6 increase of 62 msec. clotrimazole
Parkinsonism and one placebo-treated patient discontinued due to an adverse event. Risperidone is extensively metabolized in the liver. The main metabolic pathway is through hydroxylation of risperidone to 9-hydroxyrisperidone by the enzyme, CYP 2D6. A minor metabolic pathway is through N-dealkylation. The main metabolite, 9-hydroxyrisperidone, has similar pharmacological activity as risperidone. Consequently, the clinical effect of the drug results from the combined concentrations of risperidone plus 9-hydroxyrisperidone. Do not divide, crush, or chew. If a total daily oral dose of at least 2 mg once daily is well tolerated, the long acting intramuscular formulation may be used. Weight gain observed with atypical antipsychotic therapy, including risperidone.
Orally Disintegrating Tablets are etched on one side with "R0. So I give the Risperidone up all together, and became nuts in the head again with thoughts and garbage flying everywhere in my head. So back on the generic I went. Since I switched to generic, the combo of Risperidone and Clonazepam has caused me much trouble with wetting the bed. I've tried to go off the Risperidone numerous times, but always got back on it due to the craziness in my head. The only complaint I have about Risperidone, is that the Generic isn't as good. Also, it makes me go crazy upon taking it. So I take it right before bedtime, literally. It is a wonderful drug because I have most of my mind and life back. Even though I've gained 150 lbs and have unpleasant side effects. It's great knowing I can have myself back, not all, but most of my old self with the amazing help of Risperidone. Rectal Dos age: 25 mg twice daily. Gurabo, Puerto Rico 00778. DSM-IV criteria for autistic disorder. Do not hold the glass syringe barrel. This may cause the white collar to loosen or detach. Risperdal has been shown to increase the risk of death in elderly patients with dementia. More elderly dementia patients have died from pneumonia, cardiac failure and stroke while Risperdal and the increased risk was not related to the dose amount or how long the medication had been taken. Because of the number of deaths, the FDA required that a “black box warning” be added to prescribing information for Risperdal. A black box waring is the most severe warning that can be issued by the FDA and requires that information is printed at the top of prescribing information, surrounded by a thick, black border. Ereshefsky L, Saklad SR, Jann MW et al. Future of depot neuroleptic therapy: pharmacokinetic and pharmacodynamic approaches. J Clin Psychiatry. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication not have serious side effects. McDougle CJ, Scahill L, Aman MG et al. Risperidone for the core symptom domains of autism: results from the study by the Autism Network of the Research Units on Pediatric Psychopharmacology. Am J Psychiatry. When initiating an enzyme inducer while receiving risperidone, the risperidone dose may need to be increased up to double. topamax
Substance-induced psychotic disorder: This condition is caused by the use of or withdrawal from drugs, such as hallucinogens and crack cocaine, that cause hallucinations, delusions, or confused speech. This medication passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding. Hirschfeld RM, Keck PE Jr, Kramer M et al. Rapid antimanic effect of risperidone monotherapy: a 3-week multicenter, double-blind, placebo-controlled trial. Am J Psychiatry. Akathisia includes akathisia and restlessness. To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully. The majority of relapses were due to manic rather than depressive symptoms. As with other drugs that antagonize dopamine D 2 receptors, risperidone elevates prolactin levels and the elevation persists during chronic administration. Risperidone is associated with higher levels of prolactin elevation than other antipsychotic agents. When the enzyme inducer is stopped, may need to decrease the oral risperidone dose. Hyperglycemia, sometimes severe and associated with ketoacidosis, hyperosmolar coma, or death, reported in patients receiving atypical antipsychotic agents, including risperidone. Clinical monitoring of weight is recommended during treatment. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs. Kent JM, Kushner S, Ning X et al. Risperidone dosing in children and adolescents with autistic disorder: a double-blind, placebo-controlled study. J Autism Dev Disord. Agitation and restlessness may also occur. Etminan M, Streiner DL, Rochon PA. Exploring the association between atypical neuroleptic agents and diabetes mellitus in older adults. Pharmacotherapy. What treatments are available for depression? Pooled data from the three placebo-controlled, 6-week, fixed-dose studies in adult subjects with schizophrenia provided information regarding treatment-emergent EPS. Several methods were used to measure EPS: 1 the Simpson-Angus global score mean change from baseline which broadly evaluates Parkinsonism, 2 the Barnes Akathisia Rating Scale global clinical rating score mean change from baseline which evaluates akathisia, 3 use of anticholinergic medications to treat emergent EPS Table 7 and 4 incidence of spontaneous reports of EPS Table 8. For the Simpson-Angus Scale, spontaneous EPS reports and use of anticholinergic medications, there was a dose-related increase observed for the 9 mg and 12 mg doses.
Overdose symptoms may include drowsiness, fast heart rate, feeling light-headed, fainting, and restless muscle movements in your eyes, tongue, jaw, or neck. FDA product labels and may differ in countries outside the USA. Every effort has been made to ensure that the information provided on this page is accurate, up-to-date and complete, but no guarantee is made to that effect. Drugs. Risperidone and 9-hydroxyrisperidone are present in human breast milk. Because of the potential for serious adverse reactions in nursing infants from risperidone, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Do not touch spike tip at any time. Fisk, M. 10 September 2012. Consult WARNINGS section for additional precautions. It is very important to completely while using this nicotine product. Insert a cartridge into the mouthpiece and inhale the by quickly puffing on the mouthpiece for four 5-minute sessions or continually for about 20 minutes. Although using the inhaler is like a cigarette, you not need to inhale deeply as you would a cigarette for the medicine to work. Do not open the blister until ready to administer. For single tablet removal, separate one of the four blister units by tearing apart at the perforations. Bend the corner where indicated. Peel back foil to expose the tablet. DO NOT push the tablet through the foil because this could damage the tablet. Hold vial adapter by skirt to keep stationary. Risperdal's efficacy at in teens was studied in two trials, each lasting six to eight weeks. Patients either took Risperdal or a without knowing which they were taking. Stopping is hard and your chance of success is best when you are ready and have made a commitment to quit. This information should not be used to decide whether or not to take liothyronine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about liothyronine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to liothyronine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using liothyronine. IM every 2 weeks; however, efficacy of this dosage not evaluated in clinical trials. 103 Administer oral risperidone with the first IM risperidone injection and continue oral supplementation for 3 weeks thereafter. Tablets should not be chewed, divided, or crushed. The medication is contained within a nonabsorbable shell designed to release the drug at a controlled rate. The tablet shell, along with insoluble core components, is eliminated from the body; patients should not be concerned if they occasionally notice in their stool something that looks like a tablet. What is the general approach to treating depression? Holt RI. Consensus development conference on antipsychotic drugs and obesity and diabetes: response to consensus statement. Diabetes Care. purchase cipro forum
Anon. Aspartame and other sweeteners. Med Lett Drugs Ther. Because elderly patients may have diminished renal function, dose adjustments may be required according to their renal function status. In general, recommended dosing for elderly patients with normal renal function is the same as for younger adult patients with normal renal function. Do not touch spike tip at any time. This will result in contamination. Nearly impossible to take for me, anyway. Try to, maybe even ask for an older antipsychotic, Typical type. This stuff worked well and then turned me into a bed wetting maniac, all hopped up, all day long! The broken-off cap can be discarded. There is no known treatment for established tardive dyskinesia, although the syndrome may remit, partially or completely, if antipsychotic treatment is withdrawn. Antipsychotic treatment itself may suppress or partially suppress the signs and symptoms of the syndrome and may thus mask the underlying process. The effect of symptomatic suppression on the long-term course of the syndrome is unknown. In patients with hepatic impairment, pharmacokinetics were similar to those in young healthy adults; however, the mean free-fraction of risperidone in plasma was increased by about 35% due to diminished albumin and α 1-acid glycoprotein concentrations. 1 Dosage adjustment recommended. 1 See Special Populations under Dosage and Administration. Use: As monotherapy or as adjunctive therapy with lithium or valproate for the treatment of acute manic or mixed episodes associated with Bipolar I Disorder. The subjects in this multi-center, double-blind, placebo-controlled study were adult patients who met DSM-IV criteria for Bipolar Disorder Type I and who were stable on risperidone oral or long-acting injection were stable on other antipsychotics or mood stabilizers, or were experiencing an acute episode. What is risperidone Risperdal? There is no specific antidote to paliperidone, therefore, appropriate supportive measures should be instituted and close medical supervision and monitoring should continue until the patient recovers. Consideration should be given to the extended-release nature of the product when assessing treatment needs and recovery. Multiple drug involvement should also be considered. The following adverse reactions have been identified during postapproval use of risperidone; because these reactions are reported voluntarily from a population of uncertain size, it is not possible to reliably estimate their frequency: agranulocytosis, alopecia, anaphylactic reaction, angioedema, atrial fibrillation, blood cholesterol increased, blood triglycerides increased, diabetes mellitus, diabetic ketoacidosis in patients with impaired glucose metabolism, drug withdrawal syndrome neonatal, dysgeusia, hypoglycemia, hypothermia, ileus, inappropriate antidiuretic hormone secretion, intestinal obstruction, jaundice, mania, pancreatitis, priapism, QT prolongation, sleep apnea syndrome, thrombocytopenia, urinary retention, and water intoxication. Those study participants who took Risperdal were started on half a milligram nightly, with the dosage then increased to a maximum of 2 milligrams. The effects of paliperidone on the QT interval were evaluated in a double-blind, active-controlled moxifloxacin 400 mg single dose multicenter QT study in adults with schizophrenia and schizoaffective disorder, and in three placebo- and active-controlled 6-week, fixed-dose efficacy trials in adults with schizophrenia. Instructions for Use to help ensure successful administration.
Neither clinical studies nor epidemiologic studies conducted to date have shown an association between chronic administration of this class of drugs and tumorigenesis in humans, but the available evidence is too limited to be conclusive. Empujar la tapa plástica a rosca del frasco hacia abajo girándola al mismo tiempo en el sentido contrario a las manecillas del reloj. While this medication will help to manage associated symptoms, it will not cure bipolar issues, mania, autism, or schizophrenia. IM dosage not evaluated in clinical trials. 103 See Special Populations under Dosage and Administration and also see Interactions. Citrome L, Jaffe A, Levine J et al. Relationship between antipsychotic medication treatment and new cases of diabetes among psychiatric inpatients. Psychiatr Serv. While in medical school, Maguire discovered there was very little medical literature on stuttering. But when he started reading about other disorders, including Tourette syndrome -- in which a person involuntarily shouts out words, often profanities -- he noticed that the syndrome bore similarities to a stuttering disorder: Both begin in childhood, and are more common in boys than girls. Bushe C, Leonard B. Association between atypical antipsychotic agents and type 2 diabetes: review of prospective clinical data. Br J Psychiatry Suppl. No evidence of genotoxic potential for paliperidone was found in the Ames reverse mutation test, the mouse lymphoma assay, or the in vivo rat micronucleus test. Controlled clinical trials assessing long-term use are not available; the physician who prescribes risperidone for extended periods should periodically re-evaluate the long-term risks and benefits of the drug for the individual patient. Quiroz JA, Yatham LN, Palumbo JM et al. Risperidone long-acting injectable monotherapy in the maintenance treatment of bipolar I disorder. Biol Psychiatry. Holding the white collar, snap off the white cap. Bipolar I Disorder was established in a multicenter, double-blind, placebo-controlled study of adult patients who met DSM-IV criteria for Bipolar Disorder Type I, who were stable on medications or experiencing an acute manic or mixed episode. This medication can decrease and help you to think more clearly and positively about yourself, feel less agitated, and take a more active part in everyday life. fludrocortisone money order online shop
In vitro studies showed that drugs metabolized by other CYP isozymes, including 1A1, 1A2, 2C9, 2C19, and 3A4, are only weak inhibitors of risperidone metabolism. Undesirable changes in lipid parameters observed in patients treated with atypical antipsychotics. Hyperprolactinemia may suppress hypothalamic GnRH, resulting in reduced pituitary gonadotropin secretion. This, in turn, may inhibit reproductive function by impairing gonadal steroidogenesis in both female and male patients. Galactorrhea, amenorrhea, gynecomastia, and impotence have been reported in patients receiving prolactin-elevating compounds. Long-standing hyperprolactinemia when associated with hypogonadism may lead to decreased bone density in both female and male subjects. Peel back foil from the side to expose the tablet. NutraSweet which is metabolized in the GI tract to provide phenylalanine; consult manufacturer's labeling for specific information regarding phenylalanine content of individual preparations and dosage strengths. 1 39 40 41 42 43 115 See Advice to Patients. There was one report of a case of agenesis of the corpus callosum in an infant exposed to risperidone in utero. This dose produced plasma AUC levels of risperidone plus paliperidone which were about two thirds of those observed in humans at the MRHD. If you plan to have any type of surgery, including oral surgery, your surgeon or anesthesiologist needs to know that you are taking this medication.
All ratings returned to baseline at the predose assessment of the next injection 2 weeks later. No moderate or severe reactions were observed in any subject. The manufacturers recommend monitoring of weight during risperidone therapy. 1 103 115 See Hyperglycemia and Diabetes Mellitus under Cautions. Data are pooled from two studies. In vitro, drugs metabolized by CYP1A1, CYP1A2, CYP2C9, CYP2C19, and CYP3A4 only weakly inhibit risperidone metabolism. Although the prevalence of the syndrome appears to be highest among the elderly, especially elderly women, it is impossible to predict which patients will develop the syndrome. Whether antipsychotic drug products differ in their potential to cause tardive dyskinesia is unknown. amoxicillin
Paliperidone is excreted in human breast milk. The known benefits of breastfeeding should be weighed against the unknown risks of infant exposure to paliperidone. In cases of severe extrapyramidal symptoms, anticholinergic medication should be administered. Close medical supervision and monitoring should continue until the patient recovers. The study appears online Sept. 11 in the journal JAMA Psychiatry. Risperidone may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Maximum 50 mg every 2 weeks. No cases of TTP were observed during clinical studies with paliperidone. Although cases of TTP have been reported in association with risperidone administration, the relationship to risperidone therapy is unknown. Dose adjustment for lithium is not recommended. Let your doctor know if you have phenylketonuria, as the orally disintegrating Risperdal tablets contain phenylalanine. Before you take risperidone, tell your doctor if you regularly use other medicines that make you sleepy such as cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety. They can add to sleepiness caused by risperidone. For the best possible benefit, it is important to receive each scheduled dose of this as directed. If you miss a dose, contact your doctor or right away to establish a new dosing schedule. Do not stop taking this drug abruptly as it may increase the intensity of withdrawal symptoms. Consult with your doctor before reducing or stopping this medication. You may reduce withdrawal symptoms by slowly tapering off of this medication. Risperdal also causes a number of drug interactions which may be harmful or life-threatening. After you have stopped and you have reached the best dose and schedule for you, continue at that dose. Usually, after about 3 months, your doctor will help you gradually reduce your dose until you are no longer and no longer need nicotine replacement. He was okay until Dec. of 2009. Then he went crazy with fear. He thought our city was being poisoned by the water. While at our house he was asking if we had any guns. He was so depressed, we were fearful of what he might do. He went back to his house to get some clothes. While there, he took all of his pills trying to commit suicide. When I went to check on him. I found him with pills scattered all over the floor and said he took most of them. I called 911. He spent 3 weeks in a hospital in Spokane, WA. They realized the shot was the best course to treatment. He has been on the shot since then and doing quite well. Tell your doctor if your condition lasts or gets worse. Do not substitute ANY components of the dose pack.
Sleight AJ, Koek W, Bigg DCH. Binding of antipsychotic drugs at α 1A- and α 1B-adrenoceptors: risperidone is selective for the α 1B-adrenoceptors. Eur J Pharmacol. McGlennon D, Bushe CJ. Olanzapine long-acting injection: insights from an early case series in the UK. Ther Adv Psychopharmacol. The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables. CYP2D6, CYP2E1, CYP3A4, and CYP3A5. Therefore, paliperidone is not expected to inhibit clearance of drugs that are metabolized by these metabolic pathways in a clinically relevant manner. Paliperidone is also not expected to have enzyme inducing properties. De Deyn PP, Rabheru K, Rasmussen A et al. A randomized trial of risperidone, placebo, and haloperidol for behavioral symptoms of dementia. Neurology. Chinese hamster ovary cells. Between-group comparisons for pooled placebo-controlled trials in adults revealed no statistically significant differences between risperidone and placebo in mean changes from baseline in ECG parameters, including QT, QTc, and PR intervals, and heart rate. What about discontinuing antidepressants? Aug. 22, 2007 -- The FDA today approved the antipsychotic drug to treat in and in some youths. The recommended dose for the treatment of schizophrenia is 25 mg IM every 2 weeks. Taking antipsychotic medication during the last 3 months of pregnancy may cause problems in the newborn, such as withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles. However, you may have withdrawal symptoms or other problems if you stop taking your medicine during pregnancy. If you become pregnant while taking risperidone, do not stop taking it without your doctor's advice. Heylen SLE, Gelders YG. Risperidone: a new antipsychotic with serotonin 5-HT 2 and dopamine D 2 antagonistic properties. Clin Neuropharmacol. Check with your pharmacist about how to dispose of unused medicine. buy clavamox instrukcija
Gajwani P, Tesar GE. Olanzapine-induced neutropenia. Psychosomatics. Risperidone belongs to a class of drugs called atypical antipsychotics. Drugs with alpha-adrenergic blocking effects have been reported to induce priapism. Segment I study in which males only were treated. If you are planning pregnancy, become pregnant, or think you may be pregnant, immediately discuss with your doctor the benefits and risks of using this medication during pregnancy. Janssen Pharmaceuticals, Inc. Invega paliperidone extended-release tablets prescribing information. Titusville, NJ; 2014 Apr. The FDA asked Risperdal's maker, the drug company Janssen, to study Risperdal's use in kids and teens with schizophrenia and bipolar disorder. In addition, a delay in sexual maturation was seen at all doses in both males and females. The above effects showed little or no reversibility in females after a 12 week drug-free recovery period. Risperidone can be taken with or without food. The dosage is based on your medical condition and response to treatment. For the best possible benefit, it is important to receive each scheduled dose of this medication as directed. If you miss a dose, contact your doctor or pharmacist right away to establish a new dosing schedule. CYP 3A4 inducers to adjust for the expected increase in plasma concentrations of risperidone plus 9-hydroxyrisperidone. There were no other notable ECG changes. If any of these effects persist or worsen, tell your doctor or promptly. What other drugs will affect risperidone Risperdal? The possibility of obtundation, seizures, or dystonic reaction of the head and neck following overdose may create a risk of aspiration with induced emesis.
Neither clinical studies nor epidemiologic studies conducted to date have shown an association between chronic administration of this class of drugs and tumorigenesis in humans; the available evidence is considered too limited to be conclusive at this time. Brodaty H, Ames D, Snowdon J et al. A randomized placebo-controlled trial of risperidone for the treatment of aggression, agitation, and psychosis of dementia. J Clin Psychiatry. Do not place vial adapter on at an angle or diluent may leak upon transfer to the vial. Check with your doctor if you experience trembling or shaking of the hands, nervousness, difficulty sleeping, headache, change in appetite, diarrhea, weight loss, increased sweating, increased sensitivity to heat, increased heart rate, chest pain, or shortness of breath. These symptoms may mean that your dose needs to be adjusted. Do not adjust your dose or stop taking liothyronine without checking with your doctor. Bipolar I disorder was demonstrated in a 3-week, randomized, double-blind, placebo-controlled, multicenter trial including patients ranging in ages from 10 to 17 years who were experiencing a manic or mixed episode of bipolar I disorder. Hyperglycemia, in some cases extreme and associated with ketoacidosis or hyperosmolar coma or death, has been reported with the use of atypical antipsychotic agents. Patients with diabetes should be monitored for worsening control of blood glucose when treated with these agents. It is recommended that patients with risk factors for diabetes mellitus starting treatment with atypical antipsychotics should undergo fasting blood glucose testing at the beginning of treatment, and periodically thereafter. Any patient treated with atypical antipsychotics should be monitored for symptoms of hyperglycemia including polydipsia, polyuria, polyphagia, and weakness. Patients who develop symptoms of hyperglycemia during treatment with atypical antipsychotics should undergo fasting blood glucose testing. In some cases, hyperglycemia has resolved when treatment with these agents was discontinued; however, some patients required continuation of anti-diabetic treatment despite discontinuation of the atypical antipsychotic drug. While the pharmacokinetics of risperidone in subjects with liver disease were comparable to those in young healthy subjects, the mean free fraction of risperidone in plasma was increased by about 35% because of the diminished concentration of both albumin and α 1-acid glycoprotein. Paliperidone is the major active metabolite of risperidone. Overdose experience reported with risperidone can be found in the OVERDOSAGE section of the risperidone package insert. Patients with clinically significant neutropenia should be carefully monitored for fever or other symptoms or signs of infection and treated promptly if such symptoms or signs occur. Attendant risk with psychotic illnesses; closely supervise high-risk patients. buy canadian aldactone
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Conley RR. Risperidone side effects. J Clin Psychiatry. 2000; 61suppl 8: 20-3. This medication may increase a certain natural substance made by your body. Orally Disintegrating Tablet on the tongue. order esomeprazole use esomeprazole
There is no specific antidote to risperidone. Therefore, appropriate supportive measures should be instituted. The possibility of multiple drug involvement should be considered. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Risperdal, I developed a severe bladder problem, in which I had no control over my bladder. I wet the bed every single night. It really was a huge disruption in my life. This is when my Medicaid plan went to a genericHowever, I'm not so sure the generic was the problem. One thing was, on the name brand, I did extremely well!
If you are taking other prescription drugs or supplements you should check with your doctor or pharmacist before you take this medication. If you have ever experienced with street drugs or a prescription medication, let your doctor know before you begin taking this drug. The study demonstrated the efficacy of high-dose risperidone, but it did not demonstrate efficacy for low-dose risperidone. Because it only requires going to the doctor once a month, injectable paliperidone palmitate may make it more likely a person will comply with his or her treatment plan, doctors say. Our Risperdal Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. articles. bardi.info clozaril
Orally for the treatment alone or in combination with lithium or valproate of acute manic or mixed episodes associated with bipolar I disorder bipolar mania. Blue No. 2 Aluminum Lake. NDC 50458-301-04, bottles of 500 NDC 50458-301-50, and hospital unit dose blister packs of 100 NDC 50458-301-01.